Comparative Activity of Carbapenem Antibiotics Against Gram-Negative Carbapenemase Producers of Different Groups

Antimicrobial activity of copper surfaces against carbapenemase-producing contemporary Gram-negative clinical isolates.

OBJECTIVES The antimicrobial activity of copper surfaces against a variety of contemporary carbapenemase-producing Gram-negative bacteria representative of the most problematic nosocomial pathogens worldwide was evaluated. METHODS Twenty-four clinical isolates, comprising four of Escherichia coli, two of Enterobacter spp., eight of Klebsiella pneumoniae and five each of Pseudomonas aeruginosa...

In Vitro Activity of Cefiderocol against Multi-Drug Resistant Carbapenemase-Producing Gram-Negative Pathogens

Synergistic effect of clinically used antibiotics and peptide antibiotics against Gram-positive and Gram-negative bacteria

Ribosomally synthesized (natural) peptides demonstrate antimicrobial potency and may represent a novel therapeutic approach for the treatment of infections. The aim of the present study was to investigate the interaction between polycationic peptides and clinically used antimicrobial agents in the treatment of clinical isolates of Gram-positive and Gram-negative aerobic bacteria in vitro, using...

Antimicrobial activity of metal oxide nanoparticles against Gram-positive and Gram-negative bacteria: a comparative study

BACKGROUND Nanomaterials have unique properties compared to their bulk counterparts. For this reason, nanotechnology has attracted a great deal of attention from the scientific community. Metal oxide nanomaterials like ZnO and CuO have been used industrially for several purposes, including cosmetics, paints, plastics, and textiles. A common feature that these nanoparticles exhibit is their anti...

Comparative in Vitro Activity of Zydotum against Gram Negative and Gram Positive Clinical Isolates

The present study was carried out to evaluate and compare the in vitro activity of BL BLI combinations containing sulbactam and tazobactam. Drugs evaluated include ceftazidime+sulbactam (Zydotum) ceftazidime+tazobactam (Combitaz), cefoperazone+sulbactam (Sulprazon), pipercillin+tazobactam (Tazocin) and ceftazidime (C-ZID) alone against gram-negative organisms obtained from different clinical sp...